Maura Dandri Selected Research

myrcludex-B

1/2022	Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo.
1/2019	Hepatitis delta virus persists during liver regeneration and is amplified through cell division both in vitro and in vivo.
1/2019	T cell receptor grafting allows virological control of Hepatitis B virus infection.
1/2018	Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo.
5/2013	The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus.
3/2012	Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation.

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Maura Dandri Research Topics

Disease

44	Infections 03/2024 - 01/2002
15	Chronic Hepatitis B 11/2023 - 09/2006
11	Viremia 11/2023 - 09/2007
8	Coinfection 11/2023 - 03/2012
8	Hepatocellular Carcinoma (Hepatoma) 04/2021 - 09/2012
7	Hepatitis B 11/2023 - 03/2008
6	Persistent Infection 03/2024 - 01/2005
5	Liver Diseases (Liver Disease) 11/2023 - 01/2003
4	Virus Diseases (Viral Diseases) 11/2023 - 09/2012
4	Liver Cirrhosis (Hepatic Cirrhosis) 04/2021 - 01/2013
4	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2018 - 07/2010
3	Chronic Hepatitis D 11/2023 - 01/2023
3	Fibrosis (Cirrhosis) 01/2023 - 01/2020
3	Disease Progression 11/2022 - 05/2012
3	Reinfection 01/2022 - 01/2018
3	Neoplasms (Cancer) 12/2017 - 04/2011
2	Hepatitis D 01/2023 - 01/2020
1	Esophageal and Gastric Varices (Esophageal Varices) 01/2023
1	Chronic Hepatitis (Chronic Active Hepatitis) 01/2023
1	Hepatitis 01/2023
1	Hypertension (High Blood Pressure) 04/2021
1	Obesity 04/2021
1	Coronary Disease (Coronary Heart Disease) 04/2021
1	Focal Nodular Hyperplasia 01/2019
1	Inflammation (Inflammations) 08/2015
1	Acute Liver Failure (Fulminant Hepatic Failure) 02/2015
1	Liver Failure 02/2015
1	Shock 09/2014

Drug/Important Bio-Agent (IBA)

19	Antiviral Agents (Antivirals)IBA 01/2021 - 01/2005
17	Circular DNAIBA 03/2024 - 09/2006
10	RNA (Ribonucleic Acid)IBA 11/2023 - 09/2009
8	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 01/2002
6	Hepatitis B Surface Antigens (HBsAg)FDA Link 11/2023 - 09/2006
6	myrcludex-BIBA 01/2022 - 03/2012
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2008
6	VaccinesIBA 01/2021 - 01/2013
6	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 01/2018 - 01/2005
5	Interferon-alpha (Interferon Alfa)IBA 01/2017 - 02/2013
4	Biomarkers (Surrogate Marker)IBA 03/2024 - 05/2012
4	AntigensIBA 01/2018 - 05/2013
3	nasIBA 04/2021 - 01/2015
3	Peptides (Polypeptides)IBA 01/2021 - 03/2008
3	Hepatitis delta Antigens (HDAg)IBA 01/2019 - 03/2012
3	InterferonsIBA 01/2018 - 06/2011
3	entecavir FDA Link 01/2018 - 01/2017
2	Monoclonal AntibodiesIBA 11/2023 - 05/2015
2	EpitopesIBA 11/2023 - 01/2020
2	bulevirtideIBA 01/2023 - 01/2023
2	sodium-bile acid cotransporterIBA 01/2021 - 01/2019
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2019 - 08/2017
2	Viral ProteinsIBA 01/2018 - 01/2016
2	NucleosidesIBA 01/2018 - 01/2012
2	Messenger RNA (mRNA)IBA 12/2017 - 08/2017
2	Hepatitis B Core AntigensIBA 01/2017 - 05/2013
2	Plasminogen Activators (Plasminogen Activator)IBA 11/2014 - 01/2005
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2014 - 09/2012
2	LipopeptidesIBA 05/2013 - 03/2012
2	Hepatitis B e AntigensIBA 10/2008 - 09/2007
1	Immunoglobulins (Immunoglobulin)IBA 11/2023
1	Surface Antigens (Surface Antigen)IBA 11/2023
1	Broadly Neutralizing AntibodiesIBA 11/2023
1	Tenofovir (Viread)FDA Link 01/2023
1	Antinuclear AntibodiesIBA 01/2023
1	AutoantibodiesIBA 01/2023
1	Immunoglobulin G (IgG)IBA 01/2023
1	Taurocholic Acid (Sodium Taurocholate)IBA 01/2021
1	Satellite RNA (Satellite RNAs)IBA 01/2021
1	Viral AntigensIBA 01/2020
1	Toll-Like Receptor 2IBA 01/2020
1	IceIBA 01/2019
1	LigandsIBA 11/2018
1	PerforinIBA 01/2018
1	Interferon-gamma (Interferon, gamma)IBA 01/2018
1	Alanine Transaminase (SGPT)IBA 01/2018
1	Granzymes (Granzyme)IBA 01/2018
1	NVR 3-778IBA 01/2018
1	InterleukinsIBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 12/2017
1	Hepatitis B virus P proteinIBA 01/2017
1	AntibodiesIBA 05/2016
1	Virus ReceptorsIBA 05/2015
1	GlucocorticoidsIBA 02/2015
1	SteroidsIBA 02/2015
1	Lymphotoxin-alpha (Lymphotoxin)IBA 03/2014
1	CholesterolIBA 09/2012
1	Mevalonic Acid (Mevalonate)IBA 09/2012
1	Lovastatin (Mevacor)FDA LinkGeneric 09/2012
1	Monomeric GTP-Binding ProteinsIBA 09/2012
1	geranyl pyrophosphateIBA 09/2012
1	NucleotidesIBA 01/2012
1	adefovir dipivoxil (Hepsera)FDA Link 01/2008
1	Interferon-alpha2bIBA 01/2008

Therapy/Procedure

20	Therapeutics 11/2023 - 01/2003
5	Liver Transplantation 04/2021 - 03/2008
4	Transplantation 12/2017 - 01/2005
1	Duration of Therapy 01/2023
1	Contraindications 01/2023
1	Injections 08/2017
1	Intravenous Injections 05/2016
1	Aftercare (After-Treatment) 05/2013